Preheat the oven to 350°F. Oil an 9x5-inch loaf pan with canola oil cooking spray and set aside.
In a large bowl, whisk together flour, oat bran, pumpkin pie spice, baking powder, baking soda and salt. In a second large bowl, combine sugar, oil, honey, milk, pumpkin, egg and vanilla. Add wet mixture to flour mixture and stir until just combined. Fold in walnuts.
Pour batter into the prepared pan and bake until cooked through and a toothpick inserted in the middle comes out clean, about 1 hour. Cool for 15 minutes on a wire rack then remove from pan and set aside to let cool completely.
Per Serving: Serving size: 1 piece, 320 calories (150 from fat), 17g total fat, 1.5g saturated fat, 25mg cholesterol, 170mg sodium, 39g carbohydrates, (5 g dietary fiber, 19g sugar), 7g protein.
Note: We've provided special diet and nutritional information for educational purposes. But remember — we're cooks, not doctors! You should follow the advice of your health-care provider. And since product formulations change, check product labels for the most recent ingredient information. See our Terms of Service.