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Preheat the oven to 350°F. Oil an 9x5-inch loaf pan with canola oil cooking spray and set aside.
In a large bowl, whisk together flour, oat bran, pumpkin pie spice, baking powder, baking soda and salt.
Pour batter into the prepared pan and bake until cooked through and a toothpick inserted in the middle comes out clean, about 1 hour.
Cool for 15 minutes on a wire rack then remove from pan and set aside to let cool completely.