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Preheat the oven to 450°F.
In a small bowl, mix garlic powder, chili powder, salt, black pepper and cayenne.
Sprinkle evenly over both sides of tilapia.
Coat a baking sheet with 1 tablespoon of the oil.
Arrange tilapia in a single layer on the baking sheet; drizzle with the remaining tablespoon of oil.
Bake until golden brown and flesh begins to flake, 7 to 9 minutes. Serve with lime wedges on the side.